Insider Ownership

Name	Relationship / Title	Current Shares	Trading Activity
adelman robert j	Director	3,340,139	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Buy	1,214,646	n/a
11/13/2007	Acquisition (Non Open Market)	1,825,493	n/a
11/13/2007	Buy	300,000	10.00
barker jason	Officer	10,000	View
Date	Type	Shares Traded	Price Range USD
11/07/2007	Statement of Ownership	0	n/a
baskett forest	Beneficial Owner (10% or more)	4,469,274	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Statement of Ownership	0	n/a
drant ryan d	Beneficial Owner (10% or more)	4,469,274	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Statement of Ownership	0	n/a
druzgala pascal	Officer	205,288	View
Date	Type	Shares Traded	Price Range USD
08/17/2009	Disposition (Non Open Market)	17,964	n/a
10/27/2008	Disposition (Non Open Market)	15,368	n/a
11/13/2007	Acquisition (Non Open Market)	1,122	n/a
11/07/2007	Statement of Ownership	0	n/a
11/07/2007	Statement of Ownership	0	n/a
evnin luke	Beneficial Owner (10% or more)	5,364,572	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Buy	1,787,710	2.20
11/13/2007	Buy	300,000	10.00
11/13/2007	Acquisition (Non Open Market)	3,276,862	n/a
goddard paul	Officer	125,520	View
Date	Type	Shares Traded	Price Range USD
11/13/2007	Acquisition (Non Open Market)	3,021	n/a
11/07/2007	Statement of Ownership	0	n/a
11/07/2007	Statement of Ownership	0	n/a
growth equity opportunities fund, llc	Beneficial Owner (10% or more)	4,469,274	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Statement of Ownership	0	n/a
kerins patrick j	Beneficial Owner (10% or more)	4,469,274	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Statement of Ownership	0	n/a
kolluri krishna kittu	Beneficial Owner (10% or more)	4,469,274	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Statement of Ownership	0	n/a
linehan charles m	Beneficial Owner (10% or more)	4,469,274	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Statement of Ownership	0	n/a
milner peter g	Officer	319,520	View
Date	Type	Shares Traded	Price Range USD
11/13/2007	Acquisition (Non Open Market)	35,955	n/a
11/13/2007	Acquisition (Non Open Market)	11,784	n/a
11/07/2007	Statement of Ownership	0	n/a
11/07/2007	Statement of Ownership	0	n/a
mpm bioventures iii-qp l.p.	Beneficial Owner (10% or more)	5,364,572	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Buy	1,787,710	2.20
11/13/2007	Buy	300,000	10.00
11/13/2007	Acquisition (Non Open Market)	3,276,862	n/a
nomura phase4 ventures ltd	Beneficial Owner (10% or more)	2,447,731	View
Date	Type	Shares Traded	Price Range USD
11/13/2007	Acquisition (Non Open Market)	2,447,731	n/a
orbimed advisors llc	Beneficial Owner (10% or more)	1,340,139	View
Date	Type	Shares Traded	Price Range USD
05/22/2009	Sell	2,000,000	4.00
11/14/2008	Buy	1,214,646	n/a
11/13/2007	Buy	300,000	10.00
11/13/2007	Acquisition (Non Open Market)	1,825,493	n/a
simon nicholas j iii	Director	5,368,974	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Buy	1,787,710	2.20
11/13/2007	Buy	300,000	10.00
11/13/2007	Acquisition (Non Open Market)	3,276,862	n/a
11/13/2007	Acquisition (Non Open Market)	4,402	n/a
trainor iii eugene a	Beneficial Owner (10% or more)	4,469,274	View
Date	Type	Shares Traded	Price Range USD
11/14/2008	Statement of Ownership	0	n/a

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